Skip to content

Models

Generative Models

Model Class Source Conditioning Output
ProteinMPNN proteingen.models.ProteinMPNN Foundry (via rc-foundry[all]) Structure (required) (B, L, 22) logits
LigandMPNN coming soon dauparas/LigandMPNN Structure + ligands Sequence logits
ESMC (300m/600m) proteingen.models.ESMC EvolutionaryScale/esm None (masked LM) (B, L, 64) logits
ESM3 proteingen.models.ESM3 EvolutionaryScale/esm Structure (atom37 coords) (B, L, 64) logits
ESM Forge API proteingen.models.ESMForgeAPI EvolutionaryScale Forge Structure (ESM3 only) (B, L, 64) logits
DPLM-2 proteingen.models.DPLM2 bytedance/dplm None (masked diffusion) (B, L, 8229) logits
Frame2seq proteingen.models.Frame2seq dakpinaroglu/Frame2seq Structure (pdb_path, chain_id) (B, L, 22) logits
Dayhoff coming soon microsoft/Dayhoff None (masked LM) Sequence logits
ProGen3 proteingen.models.ProGen3 Profluent-AI/progen3 None (autoregressive LM) (B, L, 134) logits
EvoDiff coming soon microsoft/evodiff None (discrete diffusion) Sequence logits
SaProt coming soon westlake-repl/SaProt Structure (Foldseek tokens) Sequence logits
AMPLIFY coming soon chandar-lab/AMPLIFY None (masked LM) Sequence logits

Predictive Models

Model Class Source Conditioning Output
StabilityPMPNN proteingen.models.rocklin_ddg.PreTrainedStabilityPredictor ProteinGuide (ProteinMPNN-based) Structure (PDB → featurize) Scalar stability logit
METL coming soon gelman-lab/METL Structure (biophysics-pretrained) Fitness scalar
Tranception coming soon OATML-Markslab/Tranception MSA (retrieval-augmented) Fitness scalar